DYSPORT 500

Dysport 500 – Premium Botulinum Toxin Type A for Aesthetic and Neuromuscular Therapy

1. Overview & Manufacturer
Dysport 500 is a botulinum toxin type A product manufactured by Ipsen Biopharm Ltd., a global biopharmaceutical company headquartered in the United Kingdom. Dysport is one of the three major global botulinum toxin brands, alongside Botox® (Allergan) and Xeomin® (Merz), and is widely used in both aesthetic medicine and therapeutic neurology.

The 500-unit formulation is specifically designed for high-dose medical use and for clinics or professionals treating multiple areas in a single session.

---

2. Composition & Packaging

• Each vial of Dysport 500 contains 500 units of Clostridium botulinum toxin type A (abobotulinumtoxinA) in lyophilized powder form

• Reconstituted with 0.9% sterile sodium chloride (NaCl) before administration

• Contains human serum albumin and lactose as stabilizers

• Note: Dysport units are not interchangeable with Botox units (conversion ratio is approximately 2.5–3:1, depending on clinical context)

---

3. Mechanism of Action
Dysport acts by inhibiting the release of acetylcholine at the neuromuscular junction, thereby blocking the signal from nerve to muscle. This causes:

• Temporary muscle relaxation

• Reduction of facial expression lines

• Improved control of neuromuscular disorders

• Suppression of overactive glandular or muscle functions

---

4. Clinical Advantages

• ✅ Fast onset: Dysport may begin to work in as little as 24–48 hours, faster than many competitors

• 🌐 Proven efficacy in both cosmetic and therapeutic fields for over two decades

• 🔬 Broader diffusion profile: Useful for treating larger muscle groups or areas such as the forehead

• ⏳ Long-lasting results, typically 3 to 5 months depending on the treatment and patient response

• ⚕️ Widely used by dermatologists, plastic surgeons, and neurologists worldwide

---

5. Indications

• Aesthetic Use:

  • Glabellar lines (frown lines)

  • Horizontal forehead lines

  • Crow’s feet

  • Jawline slimming (masseter reduction)

  • Neck band relaxation (platysmal bands)

• Therapeutic Use:

  • Cervical dystonia

  • Spasticity in upper or lower limbs (post-stroke, cerebral palsy, etc.)

  • Blepharospasm and hemifacial spasm

  • Hyperhidrosis (excessive sweating)

  • Overactive bladder (off-label in some countries)

---

6. Safety & Global Certification

• Approved by FDA (U.S.), EMA (Europe), and MFDS (Korea) for multiple therapeutic and cosmetic uses

• Manufactured in GMP-certified facilities in the UK

• Supported by robust clinical trials and long-term safety data

---

7. Storage & Handling

• Store at 2–8°C, protect from light, and do not freeze

• Use the reconstituted solution within the manufacturer’s recommended period

• Only to be administered by licensed healthcare professionals with training in botulinum toxin applications