BOTOX XEOMIN

Xeomin® – Purified Botulinum Toxin Type A for Precision Aesthetic and Medical Applications

1. Overview & Manufacturer
Xeomin® is a botulinum toxin type A (incobotulinumtoxinA) product manufactured by Merz Pharmaceuticals GmbH, a German pharmaceutical company known for its innovation in medical aesthetics and neuroscience.
Xeomin is FDA-approved in the United States, EMA-approved in Europe, and used globally in both cosmetic wrinkle reduction and neurological therapies.

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2. What Makes Xeomin Unique?
Unlike other botulinum toxins, Xeomin contains no complexing proteins—only the core neurotoxin molecule. This is often referred to as the “naked toxin.”

Key benefits of this purity:

• ✅ Lower risk of antibody formation with repeated use

• ✅ Reduced likelihood of resistance over time

• ✅ Highly stable and consistent formulation

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3. Composition & Packaging

• Available in 50 U, 100 U, and 200 U vials

• Lyophilized (freeze-dried) powder requiring reconstitution with 0.9% NaCl (sterile saline)

• Manufactured to GMP standards in Germany with pharmaceutical-grade purity

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4. Mechanism of Action
Xeomin works by blocking the release of acetylcholine at the neuromuscular junction. This temporarily weakens or paralyzes muscles, leading to:

• Reduction in dynamic facial wrinkles

• Relaxation of overactive muscles

• Improved control of certain neurological conditions

• Reduced sweat gland activity

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5. Aesthetic Indications

• FDA-approved for:

  • Glabellar lines (frown lines between the eyebrows)

• Common off-label uses:

  • Forehead lines

  • Crow’s feet

  • Bunny lines (nose wrinkles)

  • Chin dimpling

  • Masseter reduction (jaw slimming)

  • Neck rejuvenation (platysmal bands)

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6. Therapeutic Indications

• FDA-approved for:

  • Cervical dystonia (neck muscle spasms)

  • Blepharospasm (eyelid spasms)

• Common off-label uses:

  • Hyperhidrosis (excessive sweating)

  • Chronic migraines

  • Spasticity (upper/lower limb)

  • TMJ dysfunction and bruxism

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7. Onset, Duration, and Dosing

• ⏱️ Onset: 3–5 days

• ⏳ Peak effect: 7–10 days

• 💡 Duration: ~3–4 months (may vary with area and dosage)

• 📊 Unit potency is roughly equivalent to Botox® (1:1 conversion)

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8. Storage & Handling

• Unreconstituted: Store at room temperature (up to 25°C), unlike many toxins that require refrigeration

• Reconstituted: Use within manufacturer’s recommended timeframe

• Gentle handling is recommended—do not shake

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9. Safety & Contraindications
Avoid use in:

• Pregnant or breastfeeding patients

• Individuals with neuromuscular disorders (e.g., myasthenia gravis)

• Patients allergic to botulinum toxin

• Active infection at the injection site

Common side effects include localized pain, bruising, temporary asymmetry, or mild muscle weakness. These are typically self-limiting.