BOTOX CORETOX

Coretox® – The World’s First Albumin-Free Botulinum Toxin Type A

1. Overview & Manufacturer
Coretox® is an advanced botulinum toxin type A (BTX-A) product developed by Medytox Inc., a leading South Korean biopharmaceutical company. It stands out as the first botulinum toxin in the world formulated without human serum albumin or animal-derived components, making it a pioneering product in safety, purity, and manufacturing innovation.

Coretox is designed for both aesthetic and therapeutic use and is positioned to meet global demands for high-purity, low-immunogenicity neuromodulators.

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2. Unique Formulation Features

• 🧬 Albumin-free and animal component-free

• 🌱 Stabilized with a proprietary peptide-based excipient instead of human-derived proteins

• 💡 Reduces risk of hypersensitivity and eliminates concerns related to blood-borne pathogen transmission

• 🛡️ Minimizes immunogenic response, making it ideal for long-term and repeat users

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3. Composition & Presentation

• Contains Clostridium botulinum toxin type A, in lyophilized (freeze-dried) powder form

• Available in 100-unit vials

• Requires reconstitution with 0.9% sterile saline (NaCl)

• Designed for GMP-level consistency, ensuring safe and stable potency in every batch

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4. Mechanism of Action
Coretox works by inhibiting the release of acetylcholine at the neuromuscular junction. This action results in:

• Temporary muscle paralysis

• Smoothing of dynamic wrinkles

• Relief of involuntary muscle contractions

• Control of glandular hyperactivity (e.g., sweating)

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5. Clinical Advantages

• ✅ First-ever albumin-free toxin: Ideal for patients with albumin sensitivity or ethical concerns

• ⏱️ Fast onset of action: Results begin in 2–4 days

• ⏳ Prolonged effect: Typically lasts 3–6 months, depending on treatment area and dosage

• 💉 Natural-looking outcomes: Smooth diffusion, optimal for both large muscle groups and fine facial lines

• 🌍 Expanding international availability due to its unique formulation and safety profile

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6. Aesthetic Indications

• Forehead lines

• Glabellar lines (frown lines)

• Crow’s feet

• Bunny lines (nose)

• Chin dimpling

• Jaw slimming (masseter reduction)

• Neck band relaxation (platysmal bands)

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7. Therapeutic Applications (off-label in some markets)

• Axillary hyperhidrosis (underarms)

• Bruxism and TMJ disorders

• Chronic migraines

• Blepharospasm

• Cervical dystonia

• Localized muscle spasticity

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8. Suggested Dosage Guidelines

Doses should be individualized based on patient assessment.

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9. Storage & Handling

• Store at 2–8°C (refrigerated); protect from light

• Reconstitute with 2.0–2.5 mL of 0.9% NaCl

• Gently roll to mix; do not shake vigorously

• Use reconstituted solution within the timeframe recommended by the manufacturer

• Only for use by licensed medical professionals

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10. Safety & Contraindications
Avoid in:

• Pregnant or breastfeeding patients

• Patients with known hypersensitivity to botulinum toxin

• Individuals with neuromuscular disorders (e.g., myasthenia gravis)

• Active infections or inflammation at the injection site

Possible side effects: mild headache, bruising, localized weakness, or temporary drooping, usually self-limiting.