BOTOX BOTAONE 100

Botaone 100 – High-Purity Botulinum Toxin Type A from South Korea for Aesthetic and Medical Excellence

1. Overview & Manufactur
Botaone 10 ibotulinum toxin type A prGenetox Co., Ltd., a trusted South Korean pharmaceutical company. It is produced using the proprietary CBFC-26 strain, and is designed to meet K-GMP standards with plans for global regulatory registration (including the MFDS and FDA) in collaboration with biotech partners like Curi Bio and DreamCIS.

Botaone stands out as a next-generation Korean neurotoxin, offering precision, stability, and safety for both aesthetic and therapeutic applications.

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2. Composition & Formulation

• 100 units of purified Clostridium botulinum toxin type A, lyophilized powder

• Requires reconstitution with 0.9% sodium chloride (saline) before use

• Albumin-free formulation: reduces potential immunogenic response

• Developed using advanced purification technology, ensuring high potency and consistency

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3. Mechanism of Action
Botaone works by blocking the release of acetylcholine at the neuromuscular junction, leading to temporary relaxation of targeted muscles. This process:

• Smooths dynamic facial wrinkles

• Reduces muscle hypertrophy (e.g., masseter, trapezius)

• Controls glandular overactivity (e.g., excessive sweating)

• Alleviates certain medical conditions involving muscle spasticity or tension

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4. Key Clinical Advantages

• ✅ High purity, low protein content → lower risk of resistance or antibody formation

• ⏱️ Quick onset → visible results typically within 2–4 days

• ⏳ Long duration → results may last 3–5 months, depending on the area and patient metabolism

• 🧬 Ethically tested → uses in vitro potency testing (not animal-based LD₅₀), enabling faster and more sustainable quality control

• 💰 Cost-effective → competitive pricing for clinics seeking a reliable, Korean-made alternative to Western brands

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5. Clinical Indications
Aesthetic Uses:

• Forehead lines

• Glabellar (frown) lines

• Crow’s feet

• Bunny lines

• Chin dimpling

• Masseter reduction (V-line slimming)

• Platysmal bands (neck)

Therapeutic (off-label) Uses:

• Hyperhidrosis (underarms, palms, soles)

• TMJ tension and bruxism

• Mild facial spasms

• Chronic migraines

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6. Dosage Guide (example, tailored to patient needs)

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7. Storage & Handling

• Store at 2–8°C; avoid freezing

• Reconstitute with 2.0–2.5 mL of saline for an approximate concentration of 4–5 U per 0.1 mL

• Roll gently—do not shake vigorously

• Use within the manufacturer’s recommended time after dilution

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8. Safety & Contraindications

• Not recommended for:

  • Pregnant or breastfeeding patients

  • Individuals with neuromuscular disorders (e.g., myasthenia gravis)

  • Active infection at the injection site

  • Known allergy to botulinum toxin ingredients

• Only for use by licensed healthcare professionals trained in toxin injection and facial anatomy